Key result
Atherosclerosis (OR 8.072), COPD (OR 2.919), diabetes (OR 2.202), and smoking (OR 1.519) were identified as independent risk factors for nonremission in depressed patients undergoing electroconvulsive therapy.
Why the study?
To explore patient clinical characteristics that may affect electroconvulsive therapy efficacy to enable improved focus during evaluations and preparation for ECT.
What are the clinical risk factors for nonremission in depressed patients undergoing electroconvulsive therapy?
Observational (n=874)
No
What are the clinical risk factors for nonremission in depressed patients undergoing electroconvulsive therapy?
Odds Ratio: 8.072 (95% CI 2.442–16.675)
p-value: p=0.001
Atherosclerosis, COPD, diabetes, and smoking are independent risk factors for nonremission in depressed patients undergoing electroconvulsive therapy.
May inform pre-ECT risk stratification in comorbid depression; leaves open prospective validation before practice change.
BACKGROUND: This study explored the patient clinical characteristics that may affect electroconvulsive therapy (ECT) efficacy to enable improved focus during evaluations and preparation for ECT. METHODS: Patients were enrolled for ECT at the Department of Psychiatry and Anesthesiology of the First Affiliated Hospital of Chongqing Medical University from December 2017 to January 2019. The primary outcome in our study was defined as the development of nonremission. A multivariate logistic analysis was performed to identify the risk factors for nonremission. RESULTS: In total, 874 depressed patients were included in the study. After the ECT treatment, 255 cases (29.2%) exhibited nonremission. A multivariate logistic regression analysis of the variables was performed, and the results showed that atherosclerosis (OR 8.072, 95% CI 2.442 to 16.675; P = 0.001), COPD (OR 2.919, 95% CI 1.240 to 6.871; P = 0.014), diabetes (OR 2.202, 95% CI 1.115 to 4.348; P = 0.023) and smoking (OR 1.519, 95% CI 1.015 to 2.273; P = 0.042) were independent risk factors for nonremission. CONCLUSION: In the retrospective analysis, we found that atherosclerosis, diabetes, COPD and smoking may be high-risk factors for nonremission.
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Zou et al. (2022) conducted an observational in Depression (n=874). Atherosclerosis, COPD, diabetes, and smoking vs. Absence of these risk factors was evaluated on Development of nonremission (HAMD-24 score > 10 after the last two consecutive ECT sessions) (OR 8.072, 95% CI 2.442-16.675, p=0.001). Atherosclerosis (OR 8.072), COPD (OR 2.919), diabetes (OR 2.202), and smoking (OR 1.519) were identified as independent risk factors for nonremission in depressed patients undergoing electroconvulsive therapy.
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