Non-Newtonian behavior of blood in a Bingham Plastic fluid model mitigated the increases in resistance to flow, apparent viscosity, and wall shear stress associated with arterial stenosis.
Does pentoxifylline-induced viscosity reduction improve blood flow characteristics in a stenosed artery model?
Numerical modeling demonstrates that the non-Newtonian behavior of blood helps limit the increase in flow resistance and shear stress in stenosed arteries, highlighting the potential biomechanical utility of viscosity-reducing drugs like pentoxifylline.
Blood-viscosity reducing drugs like “Pentoxifylline” improve blood flow by making the blood less viscous. The resistance to flow of blood in diabetic patients is higher than in non-diabetic patients. Thus diabetic patients with higher resistance to flow are more prone to high blood pressure. Therefore the resistance to blood flow in case of diabetic patients may be reduced by reducing viscosity of the plasma. Viscosity of plasma can be reducing by giving Pentoxifylline. In this paper an attempt has been made to investigate the blood flow behaviour and significance of non-Newtonian viscosity through a stenosed artery using Bingham Plastic fluid model. Numerical illustrations presented at the end of the paper provide the results for the resistance to flow, apparent viscosity and the wall shear stress through their graphical representations. It has been shown that the resistance to flow, apparent viscosity and wall shear stress increases with the size of the stenosis but these increases are comparatively small due to non-Newtonian behaviour of the blood indicating the usefulness of its rheological character in the functioning of the diseased arterial circulation.
Shah et al. (Sun,) conducted a other in Stenosed artery. Pentoxifylline was evaluated on Resistance to flow, apparent viscosity and wall shear stress. Non-Newtonian behavior of blood in a Bingham Plastic fluid model mitigated the increases in resistance to flow, apparent viscosity, and wall shear stress associated with arterial stenosis.