January 31, 2008European Neurology
Hemorheological Effects of Pentoxifylline on Disturbed Flow Behavior of Blood in Patients with Cerebrovascular Insufficiency
Why the study?
Does pentoxifylline improve hemorheologic conditions in patients with cerebrovascular insufficiency?
Population
73 patients with cerebrovascular insufficiency (CVI) and impaired hemorheologic conditions
Design
Cohort
Follow-up
4 weeks
Authors
Discussion
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Member takes
Implication
Should not yet change practice; leaves open whether hemorheologic improvements affect clinical outcomes in cerebrovascular insufficiency.
Structured PICO
Does pentoxifylline improve hemorheologic conditions in patients with cerebrovascular insufficiency?
P
Population
73 patients with cerebrovascular insufficiency (CVI) and impaired hemorheologic conditions
I
Intervention
Pentoxifylline 11-18 mg/kg orally for 4 weeks
O
Outcome
Hemorheologic conditions including red cell behavior, platelet aggregation, plasma fibrinogen, and blood viscositysurrogate
Pentoxifylline significantly improves surrogate hemorheological markers, including blood viscosity and platelet aggregation, in patients with cerebrovascular insufficiency.
Cite This Study
Ott et al. (2008) studied this question.