What question did this study set out to answer?

To elucidate the cellular and molecular mechanisms linking cytomegalovirus infection to acute rejection and chronic allograft vasculopathy in transplant recipients.

June 1, 1999Transplant Infectious Disease

Cytomegalovirus infection and cardiac allograft vasculopathy

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Authors

PKPetri KoskinenKanta-Hämeen Keskussairaala EKE.A. KallioUniversity of Helsinki JTJussi TikkanenUniversity of Helsinki

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Implication

Experimental animal study reveals bidirectional links between cytomegalovirus and vascular rejection in allografts, highlighting the long-term survival benefits of targeted antiviral therapy.

Key Points

To elucidate the cellular and molecular mechanisms linking cytomegalovirus infection to acute rejection and chronic allograft vasculopathy in transplant recipients.
Evaluated experimental rat models of aortic, cardiac, and tracheal allografts infected with rat cytomegalovirus.
Assessed intragraft leukocyte activation, intimal thickness, luminal occlusion, and cytokine and growth factor expression following viral exposure and ganciclovir treatment.
Cytomegalovirus infection triggered early inflammatory endothelialitis, increased intimal thickening in vascular allografts, and amplified growth factor and cytokine synthesis.
Ganciclovir treatment completely abolished CMV-enhanced intimal thickening and luminal occlusion while reducing inflammation, although viral immediate-early antigen expression persisted.

Cite This Study

Koskinen et al. (1999) studied this question.

synapsesocial.com/papers/6a11455f1ec7408e056a40cc https://doi.org/10.1034/j.1399-3062.1999.010205.x

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Implication

Experimental animal study reveals bidirectional links between cytomegalovirus and vascular rejection in allografts, highlighting the long-term survival benefits of targeted antiviral therapy.

Cytomegalovirus infection and cardiac allograft vasculopathy

Discussion

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Implication

Key Points

Cite This Study

Cytomegalovirus infection and cardiac allograft vasculopathy

Discussion

Member takes

Implication

Key Points

Cite This Study

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