What question did this study set out to answer?

To determine whether cytomegalovirus (CMV) infection and symptomatic CMV disease independently increase the risk of acute allograft rejection following kidney transplantation.

October 1, 2002American Journal of TransplantationOpen Access

The Impact of Cytomegalovirus Infection and Disease on Rejection Episodes in Renal Allograft Recipients

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Authors

SSSolbjørg SagedalOslo University Hospital KNKnut P. NordalOslo University Hospital AHAnders HartmannOslo University Hospital

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Implication

Prospective cohort study shows CMV infection and disease increase acute rejection risk in kidney transplant recipients, highlighting the necessity of targeted viral monitoring and control.

Key Points

To determine whether cytomegalovirus (CMV) infection and symptomatic CMV disease independently increase the risk of acute allograft rejection following kidney transplantation.
Prospective cohort study of 477 consecutive renal allograft recipients followed for 3 months without routine CMV prophylaxis, treating active CMV disease with intravenous ganciclovir.
CMV infection was monitored via leukocyte pp65 antigenemia, excluding 26 patients (HLA-identical sibling donors or repeat transplants during the study) from statistical models.
Time-dependent Cox regression analysis was performed to evaluate clinical rejection episodes and biopsy-verified rejection subtypes.
Clinical acute rejection occurred in 61% (n=277) of recipients; both CMV infection (RR = 1.6, 95% CI 1.1–2.5, p = 0.02) and CMV disease (RR = 2.5, 95% CI 1.2–5.1, p = 0.01) were independent predictors.
Biopsy-confirmed rejection occurred in 38% (n=173) of recipients (72% tubulointerstitial, 28% vascular), with CMV disease independently predicting tubulointerstitial rejection (RR = 3.1, 95% CI 1.1–9.3, p = 0.04).

Cite This Study

Sagedal et al. (2002) studied this question.

synapsesocial.com/papers/6a9247335de6664d6a6766e1 https://doi.org/10.1034/j.1600-6143.2002.20907.x

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Implication

Prospective cohort study shows CMV infection and disease increase acute rejection risk in kidney transplant recipients, highlighting the necessity of targeted viral monitoring and control.

The Impact of Cytomegalovirus Infection and Disease on Rejection Episodes in Renal Allograft Recipients

Discussion

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Implication

Key Points

Cite This Study

The Impact of Cytomegalovirus Infection and Disease on Rejection Episodes in Renal Allograft Recipients

Discussion

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Implication

Key Points

Cite This Study

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