What question did this study set out to answer?

To evaluate whether cytomegalovirus (CMV) infection acts as an etiological risk factor for subsequent allograft rejection in renal transplant recipients.

April 1, 1993Transplantation

Cytomegalovirus Infection—an Etiological Factor for Rejection? A Prospective Study in 242 Renal Transplant Patients

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Authors

CPClaire Pouteil‐NobleHospices Civils de Lyon RÉRené ÉcochardUniversité Claude Bernard Lyon 1 GLG. LandrivonService de Santé de la Jeunesse

Discussion

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Implication

Prospective cohort study shows increased graft rejection following cytomegalovirus infection in renal transplant recipients, indicating viral prevention may reduce rejection risk.

Key Points

To evaluate whether cytomegalovirus (CMV) infection acts as an etiological risk factor for subsequent allograft rejection in renal transplant recipients.
Monitored 242 consecutive renal transplant recipients prospectively for CMV infection using weekly viremia, viruria, and serology tests during the first month, followed by assessments at day 90, day 180, and every 6 months.
Defined rejection as a 25% increase in creatininemia responsive to antirejection therapy (steroids or OKT3) after ruling out cyclosporine nephrotoxicity and urological complications.
Constructed 85 matched pairs of CMV-infected and non-infected patients, assigning non-infected controls a fictitious infection date matching their partner to eliminate confounding from prior rejection episodes.
CMV infection occurred in 65% of recipients (157 of 242 patients).
In the matched analysis of 85 pairs, rejection occurring after CMV diagnosis was significantly higher in infected patients at 45% (38/85) versus 10.60% (9/85) in non-infected controls (P < 0.0001).

Cite This Study

Pouteil‐Noble et al. (1993) studied this question.

synapsesocial.com/papers/6a903155bcd42327600d2b32 https://doi.org/10.1097/00007890-199304000-00032

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Implication

Prospective cohort study shows increased graft rejection following cytomegalovirus infection in renal transplant recipients, indicating viral prevention may reduce rejection risk.

Cytomegalovirus Infection—an Etiological Factor for Rejection? A Prospective Study in 242 Renal Transplant Patients

Discussion

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Implication

Key Points

Cite This Study

Cytomegalovirus Infection—an Etiological Factor for Rejection? A Prospective Study in 242 Renal Transplant Patients

Discussion

Member takes

Implication

Key Points

Cite This Study

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