Key result
Resting heart rate ≥80 bpm linked to ~35% higher incident CKD risk vs <70 bpm.
Why the study?
Elevated resting heart rate is linked to all-cause mortality and cardiovascular events, but its association with incident chronic kidney disease among individuals with established risk factors under clinical care remains uncertain.
Does a higher resting heart rate increase the risk of incident CKD in individuals with CKD risk factors?
Cohort
Does a higher resting heart rate increase the risk of incident CKD in individuals with CKD risk factors?
A resting heart rate of ≥ 80 bpm is associated with a significantly increased risk of developing incident CKD among individuals with established CKD risk factors.
Resting heart rate ≥80 bpm may flag higher incident CKD risk; leaves open whether modification alters renal outcomes.
AIM: Elevated resting heart rate has been associated with increased risks of all-cause mortality and cardiovascular events. However, its association with the development of chronic kidney disease (CKD) among individuals with established CKD risk factors under clinical care remains uncertain. Participants were classified into three groups according to baseline heart rate: < 70 (reference), 70-79 and ≥ 80 bpm. Associations were examined using Cox proportional hazards models adjusted for demographic, clinical and treatment covariates. RESULTS: During a mean follow-up of 4.3 years, 353 participants developed CKD. Compared with the reference group (< 70 bpm), the adjusted hazard ratios for CKD were 0.94 (95% confidence interval, 0.71-1.25) in the 70-79 bpm group and 1.35 (95% confidence interval, 1.04-1.74) in the ≥ 80 bpm group. Subgroup analysis showed that the association between resting heart rate and new-onset CKD was stronger among participants with diabetes than among those without. CONCLUSION: Among individuals with CKD risk factors but without CKD at baseline, a higher resting heart rate was associated with an increased risk of incident CKD.
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Saito et al. (2026) conducted a cohort in CKD risk factors. Resting heart rate ≥ 80 bpm vs. Resting heart rate < 70 bpm was evaluated on new-onset CKD (HR 1.35, 95% CI 1.04-1.74). Among individuals with CKD risk factors, a resting heart rate ≥ 80 bpm was associated with an increased risk of incident CKD compared to < 70 bpm (HR 1.35; 95% CI 1.04-1.74).
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