Key result
Elevated HbA1c levels in subcutaneous adipose tissue are associated with immune cell expansion and depletion of structural and metabolic cell populations.
Elevated HbA1c is linked to immune cell expansion and depletion of structural and metabolic cells in subcutaneous adipose tissue.
ESCI Award for the Best Basic/Translational Research Article 2025. The ESCI Award for the Best Basic/Translational Research Article 2025 goes to ‘Cellular composition and transcriptomics of subcutaneous adipose tissue linked to blood glycated haemoglobin’ by Paulí S. et al., published in European Journal of Clinical Investigation 2025;55:e70033. The figure illustrates the key findings of the winning article: in subcutaneous adipose tissue (SAT), elevated HbA1c levels are associated with immune cell expansion and depletion of structural and metabolic cell populations. L.L. is coinventor on International Patent WO/2020/226993 filed in April 2020, relating to the use of antibodies which specifically bind IL-1α to reduce sequelae of ischaemia-reperfusion injury to the central nervous system. All other authors have nothing to declare. Data sharing not applicable to this article as no datasets were generated or analysed during the current study.
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Vilahur et al. (2026) studied Glycaemic Dysregulation. Elevated HbA1c levels in subcutaneous adipose tissue are associated with immune cell expansion and depletion of structural and metabolic cell populations.
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