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September 17, 2025Open Access

Single-Nucleus Analysis of Human White Adipose Tissue Reveals Adipocyte Subsets with Distinct Metabolic Profiles

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Authors

VEVissarion EfthymiouAGAdhideb GhoshSKSean D. Kodani

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Overview

Observational analysis uncovers distinct adipocyte profiles in human adipose tissue, indicating potential metabolic risks.

Key Points

  • Distinct adipocyte subsets were identified in human white adipose tissue, linked to various metabolic profiles.
  • High versus low expression of maturation genes categorized two types of mature adipocytes with metabolic implications.
  • Knockdown of TSHZ3 in adipogenic progenitors inhibited differentiation along with affecting fat deposition.
  • The study suggests that TSHZ3-mediated transcriptional regulation may influence metabolic disease associations.

Cite This Study

Efthymiou et al. (2025) studied this question.

synapsesocial.com/papers/68d45b1b31b076d99fa5d685https://doi.org/10.1101/2025.09.14.673351
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Defining the Human Adipose Tissue Proteome To Reveal Metabolic Alterations in Obesity2014 · 65 citations
  2. 2Distinct Developmental Profile of Lower-Body Adipose Tissue Defines Resistance Against Obesity-Associated Metabolic Complications2014 · 193 citations
  3. 32082-LB: Heterogeneity in Adipose Progenitor (AP) Populations from Subcutaneous Abdominal and Thigh Adipose Tissues of Women2024
  4. 4Cytoarchitectural multi-depot profiling reveals immune-metabolic crosstalk in human colon-associated adipose tissue2026 · 6 citations
  5. 5Single-cell DNA methylome and 3D genome atlas of human subcutaneous adipose tissue2025