What type of study is this?

This is a snm3C-seq study (also classified as: Observational).

September 10, 2025Nature GeneticsOpen Access

Single-cell DNA methylome and 3D genome atlas of human subcutaneous adipose tissue

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Authors

ZCZeyuan Johnson Chen SDSankha Subhra Das AKAsha Kar

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Overview

This research elucidates the epigenomic landscape of subcutaneous adipose tissue, highlighting distinct methylation patterns in different cell types and implications for obesity.

Key Points

SAT DNA methylation patterns reveal hypermethylation in myeloid cells and hypomethylation in adipocytes, impacting gene regulation.
We identified nearly 705,063 differentially methylated regions, which are significant in mediating transcriptional functions related to adipogenesis.
Utilizing snm3C-seq, we characterized chromosomal compartmentalization and short-range interactions that dictate cell-type lineage.
The adipocyte regions are connected to abdominal obesity traits through genome-wide association study variants, indicating a link to epigenetic regulation.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68c1cc2354b1d3bfb60f3ed8 https://doi.org/10.1038/s41588-025-02300-4

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September 10, 2025Nature GeneticsOpen Access

Single-cell DNA methylome and 3D genome atlas of human subcutaneous adipose tissue

View Full Paper

Ask AI

Bookmark

Authors

ZCZeyuan Johnson Chen SDSankha Subhra Das AKAsha Kar

Discussion

Member takes

Overview

This research elucidates the epigenomic landscape of subcutaneous adipose tissue, highlighting distinct methylation patterns in different cell types and implications for obesity.

Key Points

SAT DNA methylation patterns reveal hypermethylation in myeloid cells and hypomethylation in adipocytes, impacting gene regulation.
We identified nearly 705,063 differentially methylated regions, which are significant in mediating transcriptional functions related to adipogenesis.
Utilizing snm3C-seq, we characterized chromosomal compartmentalization and short-range interactions that dictate cell-type lineage.
The adipocyte regions are connected to abdominal obesity traits through genome-wide association study variants, indicating a link to epigenetic regulation.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68c1cc2354b1d3bfb60f3ed8 https://doi.org/10.1038/s41588-025-02300-4

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