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March 30, 2026Genome MedicineOpen Access

Lessons from single cell omics: admixed American ancestry and sex confer cardiometabolic disease risk in Mexicans

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Authors

AKAsha KarSLSeung Hyuk LeeMAMarcus Alvarez

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Overview

This research uncovers the impact of sex and ancestry on cardiometabolic disease risk in Mexicans, suggesting important genetic insights.

Key Points

  • The study aims to investigate how sex and admixed American ancestry influence cardiometabolic disease risk at the cellular level in Mexicans.
  • Generated a single nucleus RNA sequencing cohort from subcutaneous adipose tissue of Mexicans.
  • Performed differential expression testing and weighted gene co-expression analysis.
  • Conducted cis-expression quantitative trait locus (eQTL) mappings and integrated genome-wide association study (GWAS) data.
  • Identified a sex-associated adipocyte subtype linked to triglyceride biosynthesis genes.
  • Discovered 34 colocalized genes for lipid traits, with several being unique to the Mexican population.
  • Found significant sex-specific polygenic risk variants affecting serum triglycerides, highlighting ancestral genetic differences.

Cite This Study

Kar et al. (2026) studied this question.

synapsesocial.com/papers/69ca134b883daed6ee095364https://doi.org/10.1186/s13073-026-01633-x
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Also Consider

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  5. 51086-OR: An eQTL Resource of Insulin Target Tissues from Latin American Participants Reveals Ancestry-Specific Regulatory Mechanisms of Type 2 Diabetes and Lipid Traits2026