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June 7, 2026Diabetes

1086-OR: An eQTL Resource of Insulin Target Tissues from Latin American Participants Reveals Ancestry-Specific Regulatory Mechanisms of Type 2 Diabetes and Lipid Traits

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Authors

HWHARSH WADHWAŁSŁukasz SzczerbińskiFBFrancisco Barajas‐Olmos

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Overview

Randomized trial identifies eQTLs associated with type 2 diabetes in Latin Americans, suggesting new avenues for treatment.

Key Points

  • This study aims to present the LAGTEx resource to better understand regulatory mechanisms of type 2 diabetes in Latin Americans.
  • Bulk RNA-seq was conducted using Illumina Novaseq X.
  • Genotypes were imputed with TOPMed and RNA-seq counts normalized by DESeq2.
  • eQTL mapping was performed using FastQTL, adjusting for various confounders.
  • Identified 166, 2328, 700, and 219 independent cis-eQTLs in liver, SAT, VAT, and muscle respectively.
  • 211 signals colocalized with T2D GWAS loci, with 46 being novel variants.
  • SKP2 (rs10461962) colocalized in liver with PP.H4 = 0.73 and is enriched in Latin Americans.

Cite This Study

WADHWA et al. (2026) studied this question.

synapsesocial.com/papers/6a250c7d7def13d035e1ca04https://doi.org/10.2337/db26-1086-or
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1278-OR: Single-Nucleus Multiomics Profiling across 49 Individuals of Hispanic Ancestry Reveals Cell-Specific Skeletal Muscle Insulin-Responsive Gene Regulatory Signatures2024
  2. 23011-LB: Recessive GWAS Meta-analysis of 1.5M Participants Reveal Genetic Architecture of Type 2 Diabetes and Explain Ancestry-Specific Heterogeneity in Allelic Effects2026
  3. 32401-P: Genetic Regulation of Molecular Traits Enhances Precision Risk Stratification in Youth-Onset Type 2 Diabetes2026
  4. 4Multi-omic characterization of the Hispanic/Latino blood lipidome reveals an additional locus and attenuated genetic prediction2026
  5. 5Meta-analysis of lipid-traits in Hispanics identifies novel loci, population-specific effects and tissue-specific enrichment of eQTLs2016 · 71 citations