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July 26, 2026ScienceOpen Access

Human body single-cell atlas of three-dimensional genome organization and DNA methylation

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Authors

JZJingtian ZhouYWYue WuHLHanqing Liu

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Overview

Randomized trial profiles 3D genome organization and DNA methylation in various tissues, indicating significant diversity in gene regulation.

Key Points

  • To investigate how higher-order chromatin structure and DNA methylation vary across different human tissues.
  • Performed multiomic profiling of 86,689 single nuclei from 16 tissues.
  • Identified 35 major and 206 cell subtypes based on chromatin and methylation patterns.
  • Characterized 3D chromatin structure and DNA methylation at a cellular resolution.
  • Extensive changes in CG and non-CG methylation were found across different cell types.
  • Discrepancies observed between cell types based on DNA methylation versus genome structure.
  • Highlighted the variability of epigenomic features in maintaining cell identity by lineage.

Cite This Study

Zhou et al. (2026) studied this question.

synapsesocial.com/papers/6a65a468d3aea3239cd770ddhttps://doi.org/10.1126/science.adx0673
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Also Consider

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  4. 4Ontology-aware DNA methylation classification with a curated atlas of human tissues and cell types2026
  5. 5Single-cell DNA methylome and 3D genome atlas of human subcutaneous adipose tissue2025