Key result
Percutaneous PFO closure resolves persistent hypoxia and platypnea-orthodeoxia developing immediately after TTVR.
Why the study?
Platypnea-orthodeoxia syndrome had not previously been described as a complication of transcatheter tricuspid valve replacement (TTVR).
Case Report (n=1)
Persistent hypoxia with a platypnea-orthodeoxia pattern immediately after TTVR should prompt evaluation for a PFO, which can be successfully treated with percutaneous closure.
Post-TTVR hypoxia with platypnea-orthodeoxia may reflect PFO shunting; hypothesis-generating for prospective evaluation.
BACKGROUND: Transcatheter tricuspid valve replacement (TTVR) is a novel therapy for symptomatic severe tricuspid regurgitation in high-risk surgical patients. Platypnea-orthopnea syndrome has not previously been described as a complication of TTVR. CASE SUMMARY: A 76-year-old woman with symptomatic severe tricuspid regurgitation underwent successful TTVR but developed persistent hypoxia despite negative pulmonary work-up. Her hypoxia followed a platypnea-orthodeoxia pattern. Echocardiography revealed a patent foramen ovale (PFO) with right-to-left shunting. She then underwent successful percutaneous PFO closure, with resolution of her hypoxia. DISCUSSION: Acute post-TTVR anatomic and hemodynamic changes can include right atrial distortion and right ventricular dysfunction in the absence of pulmonary hypertension. These changes may acutely worsen right-sided pressures, leading to right-to-left shunting through an existing PFO. TAKE-HOME MESSAGES: Persistent hypoxia with a platypnea-orthodeoxia pattern immediately after TTVR should prompt thorough work-up including evaluation for PFO. Percutaneous PFO closure can address platypnea-orthodeoxia syndrome in this setting.
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Nguyen et al. (2026) conducted a case report in Symptomatic severe tricuspid regurgitation (n=1). Transcatheter tricuspid valve replacement (TTVR) and percutaneous PFO closure was evaluated on Resolution of hypoxia. Percutaneous PFO closure successfully resolved persistent hypoxia with a platypnea-orthodeoxia pattern that developed immediately after transcatheter tricuspid valve replacement.
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