Key result
Selective serotonin reuptake inhibitors lack adverse cardiac effects and are the preferred treatment for patients with comorbid depression and cardiovascular disease compared to tricyclic antidepressants.
Why the study?
Does the use of selective serotonin reuptake inhibitors compared to tricyclic antidepressants improve cardiovascular safety in patients with comorbid depression and cardiovascular disease?
Does the use of selective serotonin reuptake inhibitors compared to tricyclic antidepressants improve cardiovascular safety in patients with comorbid depression and cardiovascular disease?
SSRIs are the preferred pharmacological treatment for depression in patients with cardiovascular disease due to their favorable cardiac safety profile compared to tricyclic antidepressants.
Supports SSRI preference in comorbid depression and CVD; leaves open prospective RCT confirmation of long-term safety.
This review explores the epidemiological evidence for the relationship between depression and cardiovascular disease from a mechanistic standpoint. It is important to examine the biological, behavioral and social mechanisms to improve outcomes for depressed cardiac patients. A number of plausible biobehavioral mechanisms linking depression and cardiovascular disease have been identified. Tricyclic antidepressants have various effects on the cardiovascular system, while selective serotonin reuptake inhibitors are not associated with adverse cardiac effects and should, therefore, be the preferred choice for the treatment of most patients with comorbid depression and cardiovascular disease.
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Marano et al. (2009) conducted a review in Comorbid depression and cardiovascular disease. Selective serotonin reuptake inhibitors (SSRIs) vs. Tricyclic antidepressants was evaluated. Selective serotonin reuptake inhibitors lack adverse cardiac effects and are the preferred treatment for patients with comorbid depression and cardiovascular disease compared to tricyclic antidepressants.
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