March 6, 2001Circulation
Improved Surgical Outcome After Fetal Diagnosis of Hypoplastic Left Heart Syndrome
Key result
Prenatal diagnosis of hypoplastic left heart syndrome was associated with improved survival after first-stage surgery compared to postnatal diagnosis (100% vs 65.8%; P=0.009).
Why the study?
Does prenatal diagnosis improve survival after stage 1 surgery in patients with hypoplastic left heart syndrome?
Population
88 patients with hypoplastic left heart syndrome (HLHS) evaluated between July 1992 and March 1999
Comparison
Prenatal diagnosis of HLHS vs Postnatal diagnosis of HLHS
Design
Cohort
Authors
Discussion
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Member takes
Implication
May inform HLHS counseling and planning; leaves open whether prenatal diagnosis causally improves stage-1 survival.
Study Design
Type
Cohort (n=88)
Structured PICO
Does prenatal diagnosis improve survival after stage 1 surgery in patients with hypoplastic left heart syndrome?
P
Population
88 patients with hypoplastic left heart syndrome (HLHS) evaluated between July 1992 and March 1999
I
Intervention
Prenatal diagnosis of HLHS
C
Comparator
Postnatal diagnosis of HLHS
O
Outcome
Survival after stage 1 surgery, preoperative clinical status, and parental decisions regarding carehard clinical
Main Result
Absolute Event Rate: 100% vs 65.8%
p-value: p=0.009
Prenatal diagnosis of hypoplastic left heart syndrome is associated with improved preoperative clinical status and significantly higher survival rates after first-stage palliation compared to postnatal diagnosis.
Cite This Study
Tworetzky et al. (2001) conducted a cohort in Hypoplastic left heart syndrome (HLHS) (n=88). Prenatal diagnosis vs. Postnatal diagnosis was evaluated on Survival after first-stage surgery (p=0.009). Prenatal diagnosis of hypoplastic left heart syndrome was associated with improved survival after first-stage surgery compared to postnatal diagnosis (100% vs 65.8%; P=0.009).