Key result
Standard-risk fetuses with hypoplastic left heart syndrome had a significantly higher Norwood operative survival compared to high-risk fetuses (92.8% vs 56.5%, P < 0.001).
Why the study?
Does risk stratification predict Norwood operative survival in fetuses with prenatally diagnosed hypoplastic left heart syndrome?
Population
240 fetuses with prenatal diagnosis of hypoplastic left heart syndrome (HLHS)
Comparison
First-stage Norwood surgery vs Standard-risk vs High-risk categories
Design
Cohort
Follow-up
early surgical outcome
Authors
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Supports risk stratification for fetal HLHS counseling; leaves open prospective validation before guiding interventions.
Cohort (n=240)
No
Does risk stratification predict Norwood operative survival in fetuses with prenatally diagnosed hypoplastic left heart syndrome?
Absolute Event Rate: 92.8% vs 56.5%
p-value: p=< 0.001
Fetuses with prenatally diagnosed HLHS without additional risk factors have excellent early surgical survival (92.8%) following first-stage Norwood surgery, whereas those with high-risk features have significantly lower survival (56.5%).
Rychik et al. (2010) conducted a cohort in Hypoplastic left heart syndrome (HLHS) (n=240). Standard-risk status vs. High-risk status was evaluated on Norwood operative survival (p=< 0.001). Standard-risk fetuses with hypoplastic left heart syndrome had a significantly higher Norwood operative survival compared to high-risk fetuses (92.8% vs 56.5%, P < 0.001).
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