A nationwide prenatal anomaly screening programme increased detection rates of univentricular heart from 50.4% to 82.8% and transposition of great arteries from 12.3% to 41.0% (P<0.0001).
Cohort (n=645,905)
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Does a nationwide prenatal anomaly screening programme improve detection rates of univentricular heart and transposition of great arteries in pregnant women?
Implementation of a nationwide prenatal anomaly screening program significantly improved the detection rates of major congenital heart defects like UVH and TGA.
Tasa de eventos absoluta: 82.8% vs 50.4%
valor p: p=< 0.0001
OBJECTIVE: To evaluate whether a nationwide prenatal anomaly screening programme improves detection rates of univentricular heart (UVH) and transposition of great arteries (TGA), and whether maternal risk factors for severe fetal heart disease affect prenatal detection. DESIGN: Population-based cohort study. SETTING: Nationwide data from Finnish registries 2004-14. POPULATION: A total of 642 456 parturients and 3449 terminated pregnancies due to severe fetal anomaly. METHODS: Prenatal detection rates were calculated in three time periods (prescreening, transition and screening phase). The effect of maternal risk factors (obesity, in vitro fertilisation, pregestational diabetes and smoking) was evaluated. MAIN OUTCOME MEASURES: Change in detection rates and impact of maternal risk factors on screening programme efficacy. RESULTS: In total, 483 cases of UVH and 184 of TGA were detected. The prenatal detection rate of UVH increased from 50.4% to 82.8% and of TGA from 12.3% to 41.0% (P < 0.0001). Maternal risk factors did not affect prenatal detection rate, but detection rate differed substantially by region. CONCLUSIONS: A nationwide screening programme improved overall UVH and TGA detection rates, but regional differences were observed. Obesity or other maternal risk factors did not affect the screening programme efficacy. The establishment of structured guidelines and recommendations is essential when implementing the screening programme. In addition, a prospective screening register is highly recommended to ensure high quality of screening. TWEETABLE ABSTRACT: Implementation of a nationwide prenatal anomaly screening improved detection rates of UVH and TGA.
Hautala et al. (Fri,) conducted a cohort in Severe fetal heart disease (univentricular heart and transposition of great arteries) (n=645,905). Nationwide prenatal anomaly screening programme vs. Prescreening phase was evaluated on Prenatal detection rate of univentricular heart (UVH) (p=< 0.0001). A nationwide prenatal anomaly screening programme increased detection rates of univentricular heart from 50.4% to 82.8% and transposition of great arteries from 12.3% to 41.0% (P<0.0001).