Key result
Off-pump coronary artery bypass grafting showed no significant difference in long-term survival compared to on-pump surgery in a propensity-matched analysis.
Why the study?
Ongoing debates persist regarding the superiority or inferiority of off-pump coronary artery bypass grafting compared with on-pump CABG.
Does off-pump coronary artery bypass grafting improve long-term survival compared to on-pump coronary artery bypass grafting in patients undergoing isolated CABG?
Cohort (n=302)
No
Does off-pump coronary artery bypass grafting improve long-term survival compared to on-pump coronary artery bypass grafting in patients undergoing isolated CABG?
Effect estimate: HR 1.242 (95% CI 0.676-2.281)
Absolute Event Rate: 20.3% vs 13.3%
p-value: p=0.485
In experienced hands, off-pump CABG offers comparable long-term survival to on-pump CABG, even when applied to a higher-risk patient population.
No survival difference supports off-pump CABG viability in high-risk patients; leaves open confirmation by randomized trials.
Coronary artery bypass grafting (CABG) remains the most frequent surgery in the practice of an adult cardiac surgeon and the most frequently performed cardiac surgical procedure worldwide. Despite the ongoing debates regarding the superiority or inferiority of off-pump coronary artery bypass grafting, it still comprises 15-30% of all CABG cases varying in different national registries. We performed a propensity matched study of 302 consecutive CABG patients,143 off -pump cases performed by the four experienced off-pump surgeons and the on-pump CABG cases performed by those surgeons and four other experienced coronary surgeons. The five year follow up was performed and data collected comprised of mortality, rehospitalization due to cardiac origin, repeated revascularization, myocardial infarction and cerebrovascular accident. Overall, the off-pump group of patients had a higher risk profile than the patients in the on-pump group. After matching, fewer differences were found between the groups. Propensity score matching analysis showed no difference in long-term survival as well as MACCE and repeated revascularization. The higher risk profile of the patients subjected to OPCAB and the comparable survival to lower risk CPB patients in this series indicate that in experienced hands, OPCAB is a valuable option in this important subgroup of patients.
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Matković et al. (2019) conducted a cohort in Coronary artery disease (n=302). Off-pump coronary artery bypass grafting vs. On-pump coronary artery bypass grafting was evaluated on Long-term mortality (HR 1.242, 95% CI 0.676-2.281, p=0.485). Off-pump coronary artery bypass grafting showed no significant difference in long-term survival compared to on-pump surgery in a propensity-matched analysis.
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