Key result
Serum sclerostin was an independent predictor of arterial stiffness, as measured by pulse wave velocity (β -0.1472, p=0.0023), in an ambulatory population of adults.
Why the study?
Do serum concentrations of sclerostin and Dkk1 correlate with carotid intima-media thickness and arterial stiffness in an ambulatory population of adults?
Cohort (n=67)
Yes
Do serum concentrations of sclerostin and Dkk1 correlate with carotid intima-media thickness and arterial stiffness in an ambulatory population of adults?
Effect estimate: β -0.1472
p-value: p=0.0023
Serum sclerostin, but not Dkk1, is an independent predictor of arterial stiffness in an ambulatory adult population, suggesting a role in the bone-vascular axis.
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Sclerostin may mark vascular stiffness in ambulatory adults; leaves open causal role and need for longitudinal outcome studies.
Gaudio et al. (2017) conducted a cohort in Arterial stiffness and subclinical atherosclerosis (n=67). Serum sclerostin and Dkk1 levels was evaluated on Pulse wave velocity (PWV) as a measure of arterial stiffness (β -0.1472, p=0.0023). Serum sclerostin was an independent predictor of arterial stiffness, as measured by pulse wave velocity (β -0.1472, p=0.0023), in an ambulatory population of adults.
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