Key result
Native myocardial T1 mapping yields ~399 ms higher T1 times in myocarditis versus healthy subjects.
Why the study?
Existing native T1 mapping sequences for assessing cardiac anomalies are manufacturer-specific and not practicable on all machines.
Does native myocardial T1 mapping using a standard single-shot MRI pulse sequence distinguish between healthy myocardium and diffuse disease?
Observational (n=30)
Does native myocardial T1 mapping using a standard single-shot MRI pulse sequence distinguish between healthy myocardium and diffuse disease?
A standard single-shot MRI pulse sequence for native myocardial T1 mapping can effectively distinguish between healthy myocardium and diffuse cardiac disease in roughly 2 minutes.
Answers are grounded in this paper and cite their sources.
May support rapid T1 mapping to identify myocarditis; leaves open prospective validation before clinical adoption.
Cardiovascular magnetic resonance (CMR) diagnosis of acute myocarditis (AM) requires contrast injection in Late Gadolinium Enhancement (LGE). Native T1- mapping has been suggested as a potentially helpful technique in connection to the quantitative assessment of cardiac anomalies. This was demonstrated utilizing particular sequences, which are manufacturer-specific and not practicable on all machines. In this study, we propose to evaluate the capability of a standard, single-shot sequence in the clinical context to distinguish between healthy myocardium and diffuse disease. For this, 30 patients (22 participants with no cardiac involvement and 8 patients with verified cardiac involvement based on echocardiographic criteria and Troponin levels) received CMR (3-T) with LGE imaging. This analysis revealed that cardiac T1 times were significantly higher in patients with myocarditis (1516± 29ms), myocardial infarction (1596± 98ms), and pericardial effusion (1217± 12ms) than in healthy subjects (1117± 15ms). Furthermore, in roughly 2 minutes, our model reconstruction allows for single-shot myocardial T1 maps with great spatial resolution, precision, accuracy, and consistency. As it underlined the importance of T1 mapping in clinical application improvement and its contribution to direct assessment of cardiac system anomalies
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Dali et al. (2023) conducted an observational in Cardiac anomalies / Acute myocarditis (n=30). Native myocardial T1 mapping using a standard single-shot MRI pulse sequence vs. Healthy subjects was evaluated on Cardiac T1 times. Native myocardial T1 mapping using a standard single-shot MRI sequence yielded significantly higher T1 times in patients with myocarditis (1516±29ms) compared to healthy subjects (1117±15ms).
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