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January 1, 2012Journal of Cardiovascular Magnetic ResonanceOpen Access

Diagnostic performance of acute T1-mapping was superior to T2W in NSTEMI, and the likelihood of improvement of segmental function at 6 months decreased progressively as acute T1 values increased (P < 0.0004).

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Why the study?

Does pre-contrast T1-mapping by CMR improve the assessment of myocardial injury severity and prediction of functional recovery in patients with acute MI compared to standard T2W and LGE?

Population

41 patients with acute myocardial infarction at 12-48 hours after chest pain onset. STEMI patients underwent…

Comparison

3T cardiovascular magnetic resonance with… vs Standard CMR techniques

Design

Cohort

Follow-up

6 months

Authors

EDErica Dall’ArmellinaSPStefan K. PiechnikVFVanessa M. Ferreira

Discussion

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Overview

Acute T1-mapping may complement T2W for NSTEMI injury assessment; hypothesis-generating for recovery prediction, pending prospective validation.

Structured PICO

Does pre-contrast T1-mapping by CMR improve the assessment of myocardial injury severity and prediction of functional recovery in patients with acute MI compared to standard T2W and LGE?

P
Population
41 patients with acute myocardial infarction (78% STEMI) at 12-48 hours after chest pain onset. STEMI patients underwent primary PCI prior to CMR.
I
Intervention
3T cardiovascular magnetic resonance (CMR) with pre-contrast T1-mapping
C
Comparator
Standard CMR techniques (T2-weighted oedema imaging [T2W] and late gadolinium enhancement [LGE])
O
Outcome
Detection of acute myocardial injury, quantification of damage severity, and prediction of long-term functional recovery at 6 monthssurrogate

Pre-contrast T1-mapping is a valuable complementary CMR technique to LGE and T2W for identifying reversible myocardial injury and predicting functional recovery in acute MI.

Cite This Study

Dall’Armellina et al. (2012) studied this question.

synapsesocial.com/papers/6a088bf07de338f10b10c888https://doi.org/10.1186/1532-429x-14-15
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Quantification of both the area-at-risk and acute myocardial infarct size in ST-segment elevation myocardial infarction using T1-mapping2016 · 46 citations
  2. 2Hyper-acute cardiovascular magnetic resonance T1 mapping predicts infarct characteristics in patients with ST elevation myocardial infarction2020 · 23 citations
  3. 3CMR Native T1 Mapping Allows Differentiation of Reversible Versus Irreversible Myocardial Damage in ST-Segment–Elevation Myocardial Infarction2017 · 86 citations
  4. 4T2 mapping post acute myocardial infarction: a novel technique in assessing myocardial edema2024 · 2 citations
  5. 5T1 Mapping for the Diagnosis of Acute Myocarditis Using CMR2013 · 385 citations