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August 1, 2017Circulation Cardiovascular ImagingOpen Access

Acute native T1 mapping differentiated reversible from irreversible myocardial injury with a prediction accuracy of 96.7% (95% CI, 82.8% to 99.9%).

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Why the study?

Does acute native T1 mapping differentiate reversible versus irreversible myocardial injury and predict left ventricular remodeling in patients with ST-segment-elevation myocardial infarction?

Population

60 patients with ST-segment-elevation myocardial infarction

Design

Cohort

Follow-up

6 months

Key result

Acute native T1 mapping differentiated reversible from irreversible myocardial injury with a prediction accuracy of 96.7% (95% CI, 82.8% to 99.9%).

Authors

DLDan LiuHarbin University of Science and TechnologyABAlessandra BorlottiOxford Brookes UniversityDVDafne VilianiOspedale Santa Chiara

Discussion

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Overview

Supports T1 mapping for injury differentiation in STEMI; hypothesis-generating for remodeling prediction and clinical adoption.

Study Design

Type

Observational (n=60)

Structured PICO

Does acute native T1 mapping differentiate reversible versus irreversible myocardial injury and predict left ventricular remodeling in patients with ST-segment-elevation myocardial infarction?

P
Population
60 patients with ST-segment-elevation myocardial infarction evaluated with acute and 6-month 3T CMR.
E
Exposure
Acute and 6-month 3T CMR including native shortened modified look-locker inversion recovery T1 mapping
O
Outcome
Differentiation of reversible and irreversible myocardial injury and predictive value for left ventricular remodelingsurrogate

Main Result

Effect estimate: Prediction accuracy 96.7% (95% CI 82.8% to 99.9%)

Acute native T1 mapping accurately differentiates reversible from irreversible myocardial injury and strongly predicts 6-month left ventricular remodeling in STEMI patients.

Cite This Study

Liu et al. (2017) conducted an observational in ST-segment-elevation myocardial infarction (n=60). Acute native T1 mapping vs. Late gadolinium enhancement was evaluated on Differentiation of oedematous versus necrotic myocardium (Prediction accuracy 96.7%, 95% CI 82.8% to 99.9%). Acute native T1 mapping differentiated reversible from irreversible myocardial injury with a prediction accuracy of 96.7% (95% CI, 82.8% to 99.9%).

synapsesocial.com/papers/6a69e3558fdc853e08e824bdhttps://doi.org/10.1161/circimaging.116.005986
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cardiovascular magnetic resonance by non contrast T1-mapping allows assessment of severity of injury in acute myocardial infarction2012 · 284 citations
  2. 2T1-mapping inversion times of the infarcted myocardium and long term cardiovascular outcomes in St-elevation myocardial infarction2026
  3. 3Hyper-acute cardiovascular magnetic resonance T1 mapping predicts infarct characteristics in patients with ST elevation myocardial infarction2020 · 23 citations
  4. 4T1 Mapping for the Diagnosis of Acute Myocarditis Using CMR2013 · 385 citations
  5. 5T2 mapping post acute myocardial infarction: a novel technique in assessing myocardial edema2024 · 2 citations