Key result
Cardiometabolic risk factors link to worse white matter microstructure, especially higher LDL-C in APOE4 carriers.
Why the study?
White matter alterations are among the earliest changes in Alzheimer disease, but limited work has comprehensively characterized the effects of risk factors on white matter.
Do cardiometabolic risk factors affect white matter microstructure in older adults with a family history of Alzheimer's disease, and does this vary by sex and APOE genotype?
Population
Older adults with a family history of Alzheimer's disease
Comparison
Cardiometabolic risk factors stratified by sex and APOE genotype
Design
Observational study
Authors
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Supports hypothesis generation on cardiometabolic effects in AD risk; leaves open whether LDL modification alters white matter outcomes in APOE4 carriers.
Observational
Do cardiometabolic risk factors affect white matter microstructure in older adults with a family history of Alzheimer's disease, and does this vary by sex and APOE genotype?
Combined exposure to multiple cardiometabolic risk factors negatively impacts white matter microstructural health in older adults at risk for Alzheimer's disease, with LDL-cholesterol showing a distinct detrimental effect specifically in APOE4 carriers.
Tremblay et al. (2025) conducted an observational in Alzheimer's disease risk. Cardiometabolic risk factors and APOE4 genotype was evaluated on White matter microstructure alterations (Mahalanobis distance D2). Cardiometabolic risk factors negatively impact white matter microstructure in older adults with a family history of AD, with LDL-cholesterol having a specifically detrimental effect in APOE4 carriers.
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