Key result
High loaded breathing induced significant neural activation in the right anterior insula, cerebellar vermis, and medial pons (Z scores > 4.41) compared with an unloaded control condition.
Why the study?
What are the neural substrates for the perception of acutely induced dyspnea in healthy volunteers?
Population
8 healthy volunteers
Comparison
Induced respiratory discomfort by adding… vs Unloaded control condition
Authors
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Maps dyspnea networks in healthy volunteers; hypothesis-generating pilot data requiring validation in clinical populations.
What are the neural substrates for the perception of acutely induced dyspnea in healthy volunteers?
Respiratory discomfort related to loaded breathing involves distinct neural networks for the genesis/perception of the sensation and its emotional modulation.
Peiffer et al. (2001) studied Healthy volunteers (n=8). External resistive loads during inspiration and expiration vs. Unloaded control condition was evaluated on Brain activation characterized by a significant increase in regional cerebral blood flow (rCBF). High loaded breathing induced significant neural activation in the right anterior insula, cerebellar vermis, and medial pons (Z scores > 4.41) compared with an unloaded control condition.
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