Key result
Dyspnea perception involves two separate neuronal pathways for affective and intensity domains.
Why the study?
Although dyspnea pathophysiology is widely investigated across cardiopulmonary and neuromuscular diseases, less is known about the neuroanatomy of dyspnea perception.
What are the neuroanatomical correlates of dyspnea perception during breathing challenges?
Population
13 studies investigating different breathing challenges using either PET or fMRI
Comparison
Restrained breathing vs loaded breathing conditions
Design
Activation likelihood estimation meta-analysis
Authors
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Distinguishes affective from intensity processing of dyspnea; extends meta-analytic support for pathway-specific research in cardiorespiratory disease.
Meta-Analysis (n=13)
What are the neuroanatomical correlates of dyspnea perception during breathing challenges?
This meta-analysis demonstrates that two separate neuronal pathways related to either the affective or intensity domain are involved in the central processing of dyspnea perception.
Müller et al. (2025) conducted a meta-analysis in Dyspnea (n=13). Breathing challenges was evaluated on Neuroanatomical correlates of dyspnea perception. An activation likelihood estimation meta-analysis of 13 studies demonstrated that dyspnea perception involves two separate neuronal pathways related to either the affective or intensity domain.
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