Solid‐Phase Synthesis of Chiral Modular Ferrocene‐Based Peptides

Ferrocene‐containing tripeptides with one to two ferrocene building blocks were prepared by solid‐phase peptide synthesis (SPPS) using Fmoc‐protected 1′‐aminoferrocene‐1‐carboxylic acid (Fca). The conformations of the tripeptides were analysed by spectroscopic and theoretical methods. The immobilised ferrocene compounds can be reversibly oxidised on‐bead to positively charged peptides and were analysed for anion‐binding affinities by a solid‐phase binding assay. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)