What question did this study set out to answer?

To determine the temporal sequence and spatial progression of distinct amyloid beta peptide species and apolipoprotein E during early amyloid plaque deposition.

February 1, 1996Neurobiology of DiseaseOpen Access

Sequence of Deposition of Heterogeneous Amyloid β-Peptides and APO E in Down Syndrome: Implications for Initial Events in Amyloid Plaque Formation

View Full Paper

Ask AI

Bookmark

Authors

CLCynthia A. LemereBrigham and Women's Hospital JBJ. K. BlusztajnBoston University HYH YamaguchiNippon Medical School

Discussion

Member takes

Implication

Postmortem tissue study reveals that amyloid beta 42 deposition precedes apolipoprotein E accrual in Down syndrome, suggesting initial plaque seeding begins decades before clinical symptoms.

Key Points

To determine the temporal sequence and spatial progression of distinct amyloid beta peptide species and apolipoprotein E during early amyloid plaque deposition.
Examined formalin-fixed brain sections from 29 postmortem subjects with Down syndrome ranging from 3 to 73 years of age.
Quantified total amyloid plaque count and percentage of cortical area occupied across age groups using computerized image analysis and immunohistochemistry.
Aβ42 was the earliest peptide detected, present in 7 of 16 subjects aged 3–30 years (earliest at age 12), and remained more abundant than Aβ40 even in older subjects aged 51–73 years.
Aβ40 and amino-terminally modified peptides (starting at aspartate 1 or pyroglutamate 3) were not detected until approximately age 30, coinciding with the appearance of degenerating neurites.
Apolipoprotein E was detected in a subset of Aβ42 plaques beginning at age 12 and steadily increased with age, indicating that Apo E accrual occurs downstream of initial Aβ42 deposition.

Cite This Study

Lemere et al. (1996) studied this question.

synapsesocial.com/papers/6a11cc03cd406dcc8edcd748 https://doi.org/10.1006/nbdi.1996.0003

View Full Paper

Ask AI

Bookmark

Implication

Postmortem tissue study reveals that amyloid beta 42 deposition precedes apolipoprotein E accrual in Down syndrome, suggesting initial plaque seeding begins decades before clinical symptoms.

Sequence of Deposition of Heterogeneous Amyloid β-Peptides and APO E in Down Syndrome: Implications for Initial Events in Amyloid Plaque Formation

Discussion

Member takes

Implication

Key Points

Cite This Study

Sequence of Deposition of Heterogeneous Amyloid β-Peptides and APO E in Down Syndrome: Implications for Initial Events in Amyloid Plaque Formation

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider