Key result
Metoprolol succinate therapy prior to elective PCI did not significantly reduce the elevation of cardiac troponin-I levels compared to no beta-blocker (11.9% vs 6.9%; P=0.2).
Why the study?
Does metoprolol succinate reduce cardiac troponin-I elevation in patients undergoing elective PCI?
RCT (n=287)
randomized
Does metoprolol succinate reduce cardiac troponin-I elevation in patients undergoing elective PCI?
Absolute Event Rate: 11.9% vs 6.9%
p-value: p=0.2
Pre-procedural metoprolol succinate therapy does not provide a cardioprotective effect in limiting troponin-I rise after elective PCI.
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Metoprolol succinate should not be used before elective PCI to limit troponin-I elevation; confirms absence of cardioprotective effect in this setting.
Atar et al. (2006) conducted an RCT in coronary artery disease undergoing elective PCI (n=287). metoprolol succinate vs. no beta-blocker was evaluated on elevation of cardiac troponin-I levels after PCI (p=0.2). Metoprolol succinate therapy prior to elective PCI did not significantly reduce the elevation of cardiac troponin-I levels compared to no beta-blocker (11.9% vs 6.9%; P=0.2).
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