Why the study?
Are elevated plasma levels of inflammatory and endothelial dysfunction biomarkers associated with hypertension in adults from Inner Mongolia?
Observational (n=2,589)
Are elevated plasma levels of inflammatory and endothelial dysfunction biomarkers associated with hypertension in adults from Inner Mongolia?
Effect estimate: OR 1.41 (95% CI 1.06-1.86)
Elevated plasma levels of hs-CRP and angiotensin II are positively associated, and renin activity inversely associated, with the risk of hypertension, suggesting a role for inflammation and endothelial dysfunction in its pathogenesis.
Supports inflammation/endothelial dysfunction in hypertension pathogenesis; leaves open causality and need for prospective validation.
OBJECTIVE: We examined the association between plasma concentrations of high-sensitivity C-reactive protein, soluble intercellular adhesion molecule 1, soluble E-selectin, angiotensin II, renin activity and the risk of hypertension among 2589 study participants aged 20 years and older from Inner Mongolia, China. METHODS: Three blood pressure measurements were obtained using a standard mercury sphygmomanometer and hypertension was defined as blood pressure of at least 140/90 mmHg or use of antihypertensive medications. Overnight fasting blood samples were obtained to measure the biomarkers of endothelial dysfunction and inflammation. RESULTS: The average levels of high-sensitivity C-reactive protein (7.5 vs. 5.4 mg/l), soluble intercellular adhesion molecule 1 (339.4 vs. 322.6 ng/ml), soluble E-selectin (19.1 vs. 18.2 ng/ml), and angiotensin II (52.0 vs. 47.0 pg/ml) were significantly higher, whereas renin activity (1.3 vs. 1.5 mg/ml.h) was lower in hypertensive compared to normotensive participants (all P value <0.001). Compared to the lowest quartile, the multivariable-adjusted odds ratios (95% confidence interval) of hypertension for the highest quartile were 1.41 (1.06, 1.86) for high-sensitivity C-reactive protein, 1.93 (1.48, 2.53) for angiotensin II, and 0.70 (0.54, 0.91) for renin activity. CONCLUSION: Our study indicated that elevated plasma levels of high-sensitivity C-reactive protein and angiotensin II were positively and renin activity inversely associated with the risk of hypertension. These data suggest that inflammation and endothelial dysfunction may play a role in the cause of hypertension.
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Zhang et al. (2009) conducted an observational in Hypertension (n=2,589). Highest quartile of high-sensitivity C-reactive protein vs. Lowest quartile was evaluated on Hypertension (blood pressure ≥140/90 mmHg or use of antihypertensive medications) (OR 1.41, 95% CI 1.06-1.86).
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