What question did this study set out to answer?

To identify demographic, clinical, and neuropsychological factors that predict nursing home admission or mortality in patients with early-onset Alzheimer's disease.

June 1, 1987Neurology

Early‐onset Alzheimer's disease

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Authors

AHAlbert HeymanUniversity of North Carolina at Chapel Hill WWWilliam E. WilkinsonUniversity of Southampton BHBarrie J. HurwitzDuke University

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Implication

Cohort study reveals high mortality and institutionalization rates in early-onset Alzheimer's disease, indicating age and baseline cognition strongly influence prognosis.

Key Points

To identify demographic, clinical, and neuropsychological factors that predict nursing home admission or mortality in patients with early-onset Alzheimer's disease.
Conducted a 5-year follow-up study of 92 white patients diagnosed with early-onset Alzheimer's disease.
Evaluated baseline language ability, cognitive screening test scores, and overall clinical dementia ratings as potential predictors of institutional care and death.
The 5-year cumulative mortality rate was 23.9% (compared to an expected rate of 9.5%), and the 5-year cumulative rate of nursing home admission was 62.8%.
Baseline language performance, cognitive screening test scores, and overall clinical dementia severity significantly predicted both institutionalization and mortality.
Age significantly modified prognostic risk, with younger patients experiencing higher rates of institutionalization and death than older patients presenting with the same degree of severe cognitive impairment.

Cite This Study

Heyman et al. (1987) studied this question.

synapsesocial.com/papers/6a11cdec8b61bd91eb5638ca https://doi.org/10.1212/wnl.37.6.980

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Implication

Cohort study reveals high mortality and institutionalization rates in early-onset Alzheimer's disease, indicating age and baseline cognition strongly influence prognosis.

Early‐onset Alzheimer's disease

Discussion

Member takes

Implication

Key Points

Cite This Study

Early‐onset Alzheimer's disease

Discussion

Member takes

Implication

Key Points

Cite This Study

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