Key result
Early-onset Alzheimer's disease (before age 65) was associated with significantly more rapid cognitive and functional decline over 2 years compared to late-onset disease.
Why the study?
Does early-onset Alzheimer's disease increase the rate of cognitive and functional decline compared to late-onset disease in patients with probable Alzheimer's disease?
Population
127 patients with probable Alzheimer's disease (AD)
Comparison
Early-onset Alzheimer's disease vs Late-onset Alzheimer's disease
Design
Cohort
Follow-up
2 years
Authors
Discussion
Loading...
Member takes
Implication
May support intensified monitoring in early-onset cases; leaves open need for prospective trials to guide interventions.
Study Design
Type
Cohort (n=127)
Structured PICO
Does early-onset Alzheimer's disease increase the rate of cognitive and functional decline compared to late-onset disease in patients with probable Alzheimer's disease?
P
Population
127 patients with probable Alzheimer's disease (AD)
I
Intervention
Early-onset Alzheimer's disease (symptom onset before age 65)
C
Comparator
Late-onset Alzheimer's disease
O
Outcome
Rate of cognitive and functional decline measured by the modified Mini-Mental State Examination (mMMS) and the Blessed Dementia Rating Scale-Part 1 (BDRS)
Early-onset Alzheimer's disease is associated with a more rapid cognitive and functional decline and predominant impairment of attentional skills compared to late-onset disease.
Cite This Study
Jacobs et al. (1994) conducted a cohort in probable Alzheimer's disease (AD) (n=127). Early-onset Alzheimer's disease (before age 65) vs. Late-onset Alzheimer's disease was evaluated on Rate of cognitive and functional decline on the mMMS and BDRS. Early-onset Alzheimer's disease (before age 65) was associated with significantly more rapid cognitive and functional decline over 2 years compared to late-onset disease.