What question did this study set out to answer?

To determine the sequence and timing of early signs and symptoms in individuals who are subsequently diagnosed with Alzheimer's disease.

August 1, 2017BMJ OpenOpen Access

Signs and symptoms preceding the diagnosis of Alzheimer’s disease: a systematic scoping review of literature from 1937 to 2016

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Authors

FBFidelia BatureUniversity of Bedfordshire BGBarbara‐ann GuinnUniversity of Hull DPDong PangPeking University

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Implication

Systematic scoping review reveals early cognitive and depressive symptoms before Alzheimer's disease diagnosis, highlighting diagnostic challenges across clinical subtypes.

Key Points

To determine the sequence and timing of early signs and symptoms in individuals who are subsequently diagnosed with Alzheimer's disease.
Conducted a systematic scoping review across MEDLINE, PsycINFO, CINAHL, British Nursing Index, PubMed Central, and Cochrane Library databases from 1937 through May 2016 without language restriction.
Extracted study data independently using two reviewers and evaluated methodological quality using the QUADAS-2 assessment tool.
Depression and cognitive impairment presented first in 98.5% and 99.1% of patients with late-onset Alzheimer's disease (LOAD), compared to 9% and 80% in early-onset Alzheimer's disease (EOAD), with memory loss evident up to 12 years prior to clinical diagnosis in LOAD.
Rapidly progressive LOAD manifested predominantly with atypical focal signs, including myoclonus (75%), disturbed gait (66%), and rigidity, leading to initial misdiagnosis as Creutzfeldt-Jakob disease in 100% of reported cases.

Cite This Study

Bature et al. (2017) studied this question.

synapsesocial.com/papers/6a15981fa2f71238514e90cc https://doi.org/10.1136/bmjopen-2016-015746

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Implication

Systematic scoping review reveals early cognitive and depressive symptoms before Alzheimer's disease diagnosis, highlighting diagnostic challenges across clinical subtypes.

Signs and symptoms preceding the diagnosis of Alzheimer’s disease: a systematic scoping review of literature from 1937 to 2016

Discussion

Member takes

Implication

Key Points

Cite This Study

Signs and symptoms preceding the diagnosis of Alzheimer’s disease: a systematic scoping review of literature from 1937 to 2016

Discussion

Member takes

Implication

Key Points

Cite This Study

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