What is the clinical evidence from this study?

Study design: RCT. Population: chronic heart failure (n=30). Intervention: multiple micronutrient supplementation vs. placebo. Primary outcome: Change in left ventricular (LV) volumes (p=<0.05).

What question did this study set out to answer?

To determine whether long-term multiple micronutrient supplementation improves left ventricular function, inflammatory cytokine markers, and quality of life in elderly patients with chronic heart failure.

August 4, 2005European Heart JournalOpen Access

The effect of micronutrient supplementation on quality-of-life and left ventricular function in elderly patients with chronic heart failure

Q: What are the key findings of this study?

Long-term multiple micronutrient supplementation significantly reduced LV volumes (-13.1% vs +3.8%; P<0.05) and improved LVEF and quality-of-life in elderly patients with chronic heart failure.

Q: What question did this study set out to answer?

To determine whether long-term multiple micronutrient supplementation improves left ventricular function, inflammatory cytokine markers, and quality of life in elderly patients with chronic heart failure.

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Key result

Long-term multiple micronutrient supplementation significantly reduced LV volumes (-13.1% vs +3.8%; P<0.05) and improved LVEF and quality-of-life in elderly patients with chronic heart failure.

Why the study?

Does high-dose multiple micronutrient supplementation improve left ventricular function and quality-of-life in elderly patients with chronic heart failure?

Population

30 elderly patients with chronic heart failure, mean age 75.4, on stable optimal medical therapy for at…

Comparison

High-dose multiple micronutrient supplementation… vs Placebo for 9 months.

Design

RCT, randomized, double-blind

Follow-up

9 months

Authors

KWKlaus K. WitteHeart Failure & Transplant NNNikolay P. NikitinUniversity of Hull APAnita C. ParkerEast Carolina University

Discussion

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Implication

Supports adjunctive use in elderly chronic HF; extends evidence with first RCT data on remodeling and QoL.

Key Points

To determine whether long-term multiple micronutrient supplementation improves left ventricular function, inflammatory cytokine markers, and quality of life in elderly patients with chronic heart failure.
Double-blind, randomized, placebo-controlled trial of 30 elderly chronic heart failure patients (mean age 75.4 years, left ventricular ejection fraction ≤35%) on stable medical therapy for at least 3 months.
Participants received capsules containing high-dose micronutrients (minerals, vitamins A–E, and Coenzyme Q10) or placebo daily for 9 months.
Outcomes evaluated at baseline and 9 months included cardiac magnetic resonance imaging, quality-of-life questionnaires, six-minute walk tests, and inflammatory cytokines (TNF-alpha, TNFR-1, TNFR-2).
Micronutrient supplementation significantly reduced left ventricular volumes (-13.1 ± 17.1% vs. +3.8 ± 10.0% in placebo; P < 0.05) and increased left ventricular ejection fraction by 5.3 ± 1.4% (P < 0.05).
Quality-of-life scores improved significantly in the micronutrient group compared to placebo (+9.5 ± 1.6% vs. -1.1 ± 0.8%; P < 0.05).
Six-minute walk test distance and inflammatory cytokine concentrations remained unchanged across both treatment groups.

Study Design

Type

RCT (n=30)

Blinding

double-blind

Randomization

randomized

Structured PICO

Does high-dose multiple micronutrient supplementation improve left ventricular function and quality-of-life in elderly patients with chronic heart failure?

Population

30 elderly patients with chronic heart failure (LVEF ≤35%), mean age 75.4, on stable optimal medical therapy for at least 3 months.

Intervention

High-dose multiple micronutrient supplementation (calcium, magnesium, zinc, copper, selenium, vitamin A, thiamine, riboflavin, vitamin B6, folate, vitamin B12, vitamin C, vitamin E, vitamin D, and Coenzyme Q10) via capsules for 9 months.

Comparator

Placebo for 9 months.

Outcome

Left ventricular function (LV volumes and LVEF), pro-inflammatory cytokines (TNF-alpha, TNFR-1, TNFR-2), six-minute walk test, and quality-of-life (QoL) at 9 months.surrogate

Main Result

Absolute Event Rate: -13.1% vs 3.8%

p-value: p=<0.05

Long-term multiple micronutrient supplementation may improve left ventricular function and quality of life in elderly patients with heart failure with reduced ejection fraction.

Cite This Study

Witte et al. (2005) conducted an RCT in chronic heart failure (n=30). multiple micronutrient supplementation vs. placebo was evaluated on Change in left ventricular (LV) volumes (p=<0.05). Long-term multiple micronutrient supplementation significantly reduced LV volumes (-13.1% vs +3.8%; P<0.05) and improved LVEF and quality-of-life in elderly patients with chronic heart failure.

synapsesocial.com/papers/6a11ce3535a4eec8fedce026 https://doi.org/10.1093/eurheartj/ehi442

Topics

Heart failure HFrEF treatment

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The effect of micronutrient supplementation on quality-of-life and left ventricular function in elderly patients with chronic heart failure

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Topics

The effect of micronutrient supplementation on quality-of-life and left ventricular function in elderly patients with chronic heart failure

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

Topics

Also Consider