Key result
Metabolically abnormal and obese phenotype is linked to ~22% greater risk of CIMT progression.
Why the study?
The study was conducted to examine associations between metabolically obese phenotypes or their dynamic changes and increased carotid intima-media thickness.
Does the metabolically abnormal and obese phenotype increase the risk of increased carotid intima-media thickness in adults?
Cohort (n=13,681)
Does the metabolically abnormal and obese phenotype increase the risk of increased carotid intima-media thickness in adults?
Effect estimate: HR 1.22 (95% CI 1.07-1.4)
The metabolically abnormal and obese phenotype, as well as its stable presence, is significantly associated with an increased risk of carotid intima-media thickness progression.
MAO phenotype associated with CIMT progression; leaves open whether targeting metabolic status alters atherosclerosis risk.
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Yang et al. (2022) conducted a cohort in Metabolically obese phenotypes (n=13,681). Metabolically abnormal and obese (MAO) phenotype vs. Metabolically healthy and normal weight (MHNW) was evaluated on Increased carotid intima-media thickness (CIMT) (HR 1.22, 95% CI 1.07-1.4). The metabolically abnormal and obese (MAO) phenotype was significantly associated with an increased risk of carotid intima-media thickness progression (HR 1.22; 95% CI 1.07-1.40).
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