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August 21, 2025Frontiers in NutritionOpen Access

Associations of metabolic heterogeneity of obesity with the progression of cardiometabolic multimorbidity—a nationwide prospective cohort study

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Authors

NCNa CaiLZLin ZhangSDShuai Ding

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Overview

Longitudinal cohort analysis reveals obesity and metabolic status influence cardiometabolic multimorbidity incidence in adults, highlighting the critical role of metabolic health.

Key Points

  • Worsening metabolic health and obesity significantly increase the risk of cardiometabolic multimorbidity.
  • Among participants, 562 (11.15%) developed cardiometabolic multimorbidity during the follow-up period.
  • Logistic regression models demonstrated the changing metabolic status has a greater impact on CMM risk than shifts in body mass index.
  • This highlights the need for personalized obesity management strategies targeting metabolic health to reduce CMM risk.

Cite This Study

Cai et al. (2025) studied this question.

synapsesocial.com/papers/68af5228ad7bf08b1eada103https://doi.org/10.3389/fnut.2025.1617929
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