What does this research mean for the field?

Severe valvular incompetence significantly increases total stroke output of the left ventricle, and while end-systolic and total stroke volume vary directly with end-diastolic volume, there is no correlation between end-diastolic pressure and either total stroke volume or end-diastolic volume. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To measure left ventricular volumes and evaluate their relationship with intracardiac pressures and stroke output in patients with valvular heart disease.

June 1, 1964CirculationOpen Access

Left Ventricular Volumes in Valvular Heart Disease

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Population

86 patients with aortic and mitral valve disease

Design

Cross-sectional

Authors

JJJohn W. JonesSUNY Cortland CRCharles E. RackleyUniversity of North Carolina at Chapel Hill RBRobert A. BruceUniversity of Iowa

Discussion

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Implication

Challenges reliance on end-diastolic pressure for stroke volume assessment in valve disease; leaves open volume-based metrics for future validation.

Key Points

To measure left ventricular volumes and evaluate their relationship with intracardiac pressures and stroke output in patients with valvular heart disease.
Assessed left ventricular volumes in N=86 patients with aortic and mitral valve disease.
Performed biplane angiocardiography in conjunction with cardiac catheterization to determine volume and pressure dynamics.
Severe valvular incompetence grossly increased total left ventricular stroke output.
End-systolic volume and total stroke volume varied directly with end-diastolic volume.
End-diastolic pressure demonstrated no correlation with either total stroke volume or end-diastolic volume.

Structured PICO

Population

86 patients with aortic and mitral valve disease

Intervention

Biplane angiocardiographic technique in conjunction with cardiac catheterization

Outcome

Left ventricular volumes (end-systolic volume, end-diastolic volume, total stroke volume) and end-diastolic pressuresurrogate

In patients with aortic and mitral valve disease, left ventricular stroke volume correlates with end-diastolic volume but not end-diastolic pressure.

Cite This Study

Jones et al. (1964) studied this question.

synapsesocial.com/papers/6a11d076dcb035f2f8fd3bac https://doi.org/10.1161/01.cir.29.6.887

Topics

Mitral valve intervention Valvular heart disease Infective endocarditis

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Implication

Challenges reliance on end-diastolic pressure for stroke volume assessment in valve disease; leaves open volume-based metrics for future validation.

Left Ventricular Volumes in Valvular Heart Disease

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Left Ventricular Volumes in Valvular Heart Disease

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

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