Key result
Pre-pregnancy obesity linked to ~79% greater peripartum cardiomyopathy risk versus normal weight.
Why the study?
The study was conducted to assess the association between pre-pregnancy obesity and the incidence of peripartum cardiomyopathy.
Does pre-pregnancy obesity increase the incidence of peripartum cardiomyopathy compared to normal weight?
Meta-Analysis (n=5,373,581)
Does pre-pregnancy obesity increase the incidence of peripartum cardiomyopathy compared to normal weight?
Effect estimate: OR 1.79 (95% CI 1.16, 2.76)
p-value: p=0.008
Pre-pregnancy obesity is associated with a significantly increased risk of peripartum cardiomyopathy, with higher obesity classes showing greater risk.
The outcome of this review is to assess the association between pre-pregnancy obesity and PPCM incidence. There were a total of 5.373.581 participants were included in this study. Pre-pregnancy obesity was significantly associated with PPCM incidence compared to normal-weight subjects (OR = 1.79 (1.16,2.76); p = 0.008; I2 = 59%, Pheterogeneity = 0.04). The sub-group analysis showed that pre-pregnancy women with obesity class I (OR = 1.58 (1.20,2.07); p = 0.001; I2 = 0%, Pheterogeneity = 0.64) and class II and III (OR = 2.65 (2.04,3.45); p < 0.001; I2 = 6%, Pheterogeneity = 0.36) was significantly associated with PPCM incidence compared to normal-weight subjects.
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Putra et al. (2022) conducted a meta-analysis in Peripartum cardiomyopathy (PPCM) (n=5,373,581). Pre-pregnancy obesity vs. Normal weight was evaluated on Incidence of peripartum cardiomyopathy (OR 1.79, 95% CI 1.16, 2.76, p=0.008). Pre-pregnancy obesity was significantly associated with an increased incidence of peripartum cardiomyopathy compared to normal-weight subjects (OR 1.79).
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