Key result
Adult obstructive sleep apnea is linked to substantially lower adiponectin levels versus controls.
Why the study?
The association of blood levels of adiponectin in patients with obstructive sleep apnea syndrome remained challenging and unknown, with conflicting results.
Are plasma/serum adiponectin levels reduced in adult patients with OSAS compared to controls?
Meta-Analysis
Are plasma/serum adiponectin levels reduced in adult patients with OSAS compared to controls?
Effect estimate: SMD -0.71 (95% CI -0.92, 0.50)
p-value: p=< 0.00001
Adult patients with OSAS have significantly reduced plasma/serum adiponectin levels compared to controls, suggesting a potential role of this anti-inflammatory factor in OSAS pathogenesis.
Authors
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Reduced adiponectin may mark OSAS-related inflammation; leaves open causal role and therapeutic implications.
Najafi et al. (2022) conducted a meta-analysis in Obstructive Sleep Apnea Syndrome (OSAS). Plasma/serum adiponectin levels vs. Controls was evaluated on Plasma/serum adiponectin levels (SMD -0.71, 95% CI -0.92, 0.50, p=< 0.00001). Plasma/serum levels of adiponectin were significantly reduced in adult patients with obstructive sleep apnea syndrome compared to controls (SMD -0.71; 95% CI -0.92, 0.50; p<0.00001).
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