Key result
Severe OSAS is associated with decreased plasma irisin and increased RBP-4 levels compared to mild OSAS (p<0.001), with RBP-4 demonstrating 92.0% sensitivity as a predictor of OSAS.
Why the study?
The study was conducted to investigate whether plasma irisin, RBP-4, and adiponectin levels are associated with the severity of obstructive sleep apnea syndrome.
Case-Control (n=171)
p-value: p=<0.001
Plasma levels of irisin, adiponectin, and RBP-4 correlate with the severity of obstructive sleep apnea syndrome and may serve as biomarkers for associated metabolic and cardiovascular risks.
May link adipokines to OSAS severity; leaves open whether markers aid stratification or require prospective validation.
Objective: Obstructive sleep apnea syndrome (OSAS) is a common sleep disorder that is caused by the reduction or cessation of airflow in the upper airway. Irisin, retinol-binding protein-4 (RBP-4), and adiponectin are the three significant factors in the metabolic process of the human body. The objective of this study was to investigate whether plasma irisin, RBP-4, and adiponectin levels are associated with the severity of OSAS. Methods: According to inclusion and exclusion criteria, 125 patients with OSAS and 46 healthy, gender matched controls were included to the study. The patients were classified according to the apnea hypopnea index (AHI) as 14 mild cases (5 30). The plasma irisin, RBP-4 and adiponectin levels were measured and compared between groups. Results: RBP-4 levels were higher in severe OSAS compared to moderate (p<0.05) and mild (p<0.001) OSAS groups, irisin levels were significantly lower compared to moderate (p<0.05) and mild (p<0.001) OSAS groups. There was a negative correlation between irisin and RBP-4 (r=-0.379; p<0.001) and AHI (r=-0.834; p<0.001) and a positive correlation with minimum oxygen saturation (MOS) (r=0.341; p<0.001) in the patient group. In the patient group, there was a negative correlation between adiponectin and BMI (r=-0.682; p<0.001), RBP-4 (r=-0.292; p<0.01) and AHI (r=-0.179; p<0.05) and a positive correlation with MOS (r=0.397; p<0.001). In the patient group, there was a positive correlation between RBP-4 and BMI (r=0.406; p<0.001) and AHI (r=0.473; p<0.001) and a negative correlation with MOS (r=-0.805; p<0.001). As a predictor of OSAS, adiponectin showed the highest specificity (84.8%) and RBP-4 the highest sensitivity (92.0%). Conclusion: The results of the present study demonstrated that the severity of OSAS causes more metabolic problems, including decreased plasma irisin and adiponectin levels and an increased plasma RBP-4 level. As a result, patients with an AHI score greater than thirty should be closely monitored for metabolic and cardiovascular abnormalities.
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Fazlıoğlu et al. (2023) conducted a case-control in Obstructive sleep apnea syndrome (OSAS) (n=171). Obstructive sleep apnea syndrome (OSAS) vs. Healthy controls was evaluated on Plasma irisin, RBP-4, and adiponectin levels (p=<0.001). Severe OSAS is associated with decreased plasma irisin and increased RBP-4 levels compared to mild OSAS (p<0.001), with RBP-4 demonstrating 92.0% sensitivity as a predictor of OSAS.
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