Key result
Extended VTE prophylaxis is not associated with reduced 90-day VTE after complex GI cancer surgery.
Why the study?
Clinical guidelines recommend extended VTE prophylaxis for cancer patients after major GI operations, but adherence has been low and clinical outcomes not well defined.
Does extended VTE prophylaxis reduce 90-day post-discharge VTE or increase bleeding in cancer patients undergoing major GI surgery?
Cohort (n=2,069)
Yes
Does extended VTE prophylaxis reduce 90-day post-discharge VTE or increase bleeding in cancer patients undergoing major GI surgery?
Effect estimate: OR 1.54 (95% CI 0.81-2.96)
Absolute Event Rate: 6.8% vs 5.1%
p-value: p=0.19
In a retrospective cohort of cancer patients undergoing complex GI surgery, extended VTE prophylaxis was rarely prescribed and was not associated with a reduction in 90-day post-discharge VTE, challenging current guideline recommendations.
No takes yet. Share an insight, caveat, or question.
Extended prophylaxis showed no VTE reduction; hypothesis-generating and should not yet alter practice or guidelines.
Mavros et al. (2023) conducted a cohort in Cancer undergoing complex gastrointestinal surgery (n=2,069). Extended VTE prophylaxis vs. No extended VTE prophylaxis was evaluated on 90-day post-discharge VTE (OR 1.54, 95% CI 0.81-2.96, p=0.19). Extended VTE prophylaxis was not associated with a reduction in 90-day post-discharge VTE (OR 1.54) or bleeding (OR 0.72) compared to no extended prophylaxis in cancer patients undergoing complex GI surgery.
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