Key result
Hemodialysis-induced preload reduction significantly decreased septal E' velocity (7.1 to 5.9 cm/s, P=0.0003) but did not significantly alter lateral E' velocity (8.9 to 8.3 cm/s, P=0.37).
Why the study?
Does haemodialysis-induced preload reduction alter Doppler parameters of left ventricular diastolic function in patients with renal failure?
Population
45 patients, comprising 37 haemodialysis patients with end-stage renal disease and 8 ventilated ICU patients…
Comparison
Haemodialysis-induced preload reduction vs Baseline (before haemodialysis/ultrafiltration)
Design
Cohort
Follow-up
Immediate (before and after haemodialysis)
Authors
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Lateral E' may be preferred for LV diastolic assessment during preload shifts; leaves open prospective validation in renal cohorts.
Observational (n=45)
Single-blind
No
Does haemodialysis-induced preload reduction alter Doppler parameters of left ventricular diastolic function in patients with renal failure?
Absolute Event Rate: 5.9% vs 7.1%
p-value: p=0.0003
Doppler tissue imaging E' maximal velocity measured at the lateral mitral annulus is relatively insensitive to abrupt preload reduction, making it a more reliable index of LV diastolic function in this setting.
Vignon et al. (2007) conducted an observational in End-stage renal disease and acute renal failure (n=45). Hemodialysis with ultrafiltration vs. Baseline (pre-hemodialysis) was evaluated on Septal E' wave velocity (cm/s) in hemodialysis patients (p=0.0003). Hemodialysis-induced preload reduction significantly decreased septal E' velocity (7.1 to 5.9 cm/s, P=0.0003) but did not significantly alter lateral E' velocity (8.9 to 8.3 cm/s, P=0.37).