Key result
Genetic variants rs17145738 and rs3812316 of MLXIPL, and rs4846914 of GALNT2 showed no significant association with triglyceride and total cholesterol levels or the risk of ischaemic stroke.
Why the study?
Do triglyceride-modifying genetic variants in MLXIPL and GALNT2 alter lipid levels and the risk of ischaemic stroke?
Case-Control (n=623)
Do triglyceride-modifying genetic variants in MLXIPL and GALNT2 alter lipid levels and the risk of ischaemic stroke?
The studied genetic variants in MLXIPL and GALNT2 do not appear to significantly alter triglyceride levels or confer risk for ischaemic stroke in this cohort.
Answers are grounded in this paper and cite their sources.
Does not support clinical testing of these variants for stroke risk; leaves open their role in larger diverse cohorts.
BACKGROUND: Recent genome-wide studies identified several genetic variants associated with blood lipid level alterations. Because affected lipid metabolism can confer risk to the development of ischaemic stroke, we studied three polymorphisms reportedly associated with triglyceride-level changes, rs17145738 and rs3812316 of the MLXIPL locus, and rs4846914 variant of GALNT2 gene in biobanked samples of patients with stroke. This pool of samples was previously investigated for haplotype tagging minor alleles of apolipoprotein A5 gene (T-1131C, T1259C, IVS3+G476A and C56G), and an association was found between the minor allele carriage and the triglyceride levels, and also these variants were found to confer risk to the development of stroke. METHODS: Here, a total of 467 patients with stroke, stratified as large vessel, small vessel and mixed stroke groups, and 156 control subjects were genotyped using PCR-RFLP methods. RESULTS: In the current study, we could not verify association of the variants analyzed either with triglyceride and total cholesterol levels or with the risk of ischaemic stroke susceptibility. CONCLUSIONS: The data presented here revealed differentiated risk nature of the triglyceride level modifying natural gene variants.
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Polgár et al. (2010) conducted a case-control in Ischaemic stroke (n=623). MLXIPL (rs17145738, rs3812316) and GALNT2 (rs4846914) genetic variants vs. Control subjects was evaluated on Association with triglyceride and total cholesterol levels or risk of ischaemic stroke susceptibility. Genetic variants rs17145738 and rs3812316 of MLXIPL, and rs4846914 of GALNT2 showed no significant association with triglyceride and total cholesterol levels or the risk of ischaemic stroke.
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