Key result
A single high-fat meal significantly impaired flow-mediated vasodilatation, with more severe impairment in normocholesterolemic CAD patients (44.41%) than in control participants (25.99%, P<0.01).
Why the study?
Does a single high-fat meal impair endothelial function in normocholesterolemic patients with coronary artery disease compared to healthy controls?
Observational (n=75)
Does a single high-fat meal impair endothelial function in normocholesterolemic patients with coronary artery disease compared to healthy controls?
A single high-fat meal acutely impairs endothelial function, with a significantly more pronounced atherogenic effect in patients with pre-existing coronary artery disease compared to healthy controls.
Answers are grounded in this paper and cite their sources.
High-fat meals may warrant caution in CAD; this Level 3 evidence leaves open practice implications pending trials.
OBJECTIVE: To determine the effect of postprandial lipid changes on endothelial function in patients with coronary artery disease (CAD) after a high-fat meal. METHODS: We studied 50 CAD patients and 25 control participants, who were all normocholesterolemic. Flow-mediated vasodilatation of the brachial artery was evaluated by the high-resolution ultrasound technique before and after a single high-fat meal (800 calories; 50 g fat). RESULTS: Postprandial serum triglyceride level increased significantly at 2-7 h and mean flow-mediated vasodilatation was impaired significantly (from 4.22 +/- 0.44 to 2.75 +/- 0.33%, P < 0.01) for 75 subjects. The increment in 2 h serum triglyceride level correlated positively with the decrement in postprandial flow-mediated vasodilatation (r = 0.459, P < 0.01). Postprandial triglyceride level was significantly higher in CAD patients than in control participants. Flow-mediated vasodilatation was significantly impaired in CAD patients (from 3.04 +/- 0.39 to 1.69 +/- 0.23%, P < 0.01) and control participants (from 6.58 +/- 0.52 to 4.87 +/- 0.19%, P < 0.05) after a high-fat meal. The impairment of flow-mediated dilatation was more severe in CAD patients (44.41%) than in control participants (25.99%, P < 0.01). CONCLUSION: Postprandial endothelium-dependent vasodilatation after a single high-fat meal was severely impaired in normocholesterolemic CAD patients and control participants. The disordered postprandial metabolism of triglyceride-rich lipoproteins may play an atherogenic role by inducing endothelial dysfunction.
No takes yet. Share an insight, caveat, or question.
Zhao et al. (2001) conducted an observational in Coronary artery disease (n=75). Single high-fat meal vs. Control participants was evaluated on Impairment of flow-mediated vasodilatation of the brachial artery (p=<0.01). A single high-fat meal significantly impaired flow-mediated vasodilatation, with more severe impairment in normocholesterolemic CAD patients (44.41%) than in control participants (25.99%, P<0.01).
Synapse has enriched 10 related papers. Consider them for comparative context: