Key result
A single 2 g oral dose of vitamin C prevented the significant postprandial aggravation of flow-mediated dilatation observed in control subjects after a high-fat meal.
Why the study?
Does a single oral dose of vitamin C prevent postprandial endothelial dysfunction in patients with and without coronary heart disease after a high-fat meal?
Population
124 subjects, comprising 74 patients with coronary heart disease and 50 subjects without CHD but with risk…
Comparison
Single oral dose of vitamin C administered after… vs Control group receiving no vitamin C after the…
Design
Other
Follow-up
7 hours
Authors
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May blunt postprandial endothelial impairment; hypothesis-generating and should not yet change practice.
Does a single oral dose of vitamin C prevent postprandial endothelial dysfunction in patients with and without coronary heart disease after a high-fat meal?
p-value: p=0.064
A single 2 g oral dose of vitamin C preserves endothelial function against the oxidative stress induced by a high-fat meal in patients with and without coronary heart disease.
Liu et al. (2002) studied Coronary heart disease (n=124). Vitamin C vs. Control (no vitamin C) was evaluated on Postprandial flow-mediated dilatation (FMD) at 4 hours (p=0.064). A single 2 g oral dose of vitamin C prevented the significant postprandial aggravation of flow-mediated dilatation observed in control subjects after a high-fat meal.
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