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January 1, 2015Medical Science MonitorOpen Access

Antioxidant Vitamin C Prevents Decline in Endothelial Function during Sitting

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Why the study?

Does Vitamin C prevent the decline in superficial femoral artery flow-mediated dilation during prolonged sitting in men?

Population

11 men, mean age 24.2 ± 4.4 years

Comparison

Vitamin C ingested during 3 hours of sitting… vs Sitting for 3 hours without moving legs and…

Design

RCT, randomized

Follow-up

3 hours

Discussion

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Implication

Supports vitamin C to preserve SFA endothelial function during prolonged sitting; extends evidence for oxidative stress in sitting-induced vascular dysfunction.

Structured PICO

Does Vitamin C prevent the decline in superficial femoral artery flow-mediated dilation during prolonged sitting in men?

P
Population
11 men, mean age 24.2 ± 4.4 years
I
Intervention
Vitamin C (1 g at 30 min and 500 mg at 1 h 30 min) ingested during 3 hours of sitting without moving legs
C
Comparator
Sitting for 3 hours without moving legs and without Vitamin C
O
Outcome
Superficial femoral artery (SFA) flow-mediated dilation (FMD) measured hourly for 3 hourssurrogate

Oral Vitamin C supplementation prevents the acute impairment of superficial femoral artery endothelial function induced by prolonged sitting, suggesting a role for oxidative stress in sitting-induced vascular dysfunction.

Cite This Study

A 2015 study studied this question.

synapsesocial.com/papers/6a7e053b16d70b98d77d833dhttps://doi.org/10.12659/msm.893192
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of Prolonged Sitting and Breaks in Sitting Time on Endothelial Function2014 · 289 citations
  2. 2Vitamin C prevents the acute decline of flow-mediated dilation after altered shear rate patterns2012 · 34 citations
  3. 3Sitting and endothelial dysfunction: The role of shear stress2012 · 150 citations
  4. 4Assessment of flow-mediated dilation in humans: a methodological and physiological guideline2010 · 1,487 citations
  5. 5Physical Inactivity Increases Oxidative Stress, Endothelial Dysfunction, and Atherosclerosis2005 · 324 citations