Key result
Vitamin C therapy (1 g for 2 days) attenuated postprandial lipaemia-induced endothelial dysfunction at 4 hours (FMD 2.8% vs 0.22%) and 8 hours in patients with Type 2 diabetes.
Why the study?
Does vitamin C improve endothelial dysfunction induced by postprandial lipaemia in subjects with Type 2 diabetes?
RCT (n=20)
Double-blind
Does vitamin C improve endothelial dysfunction induced by postprandial lipaemia in subjects with Type 2 diabetes?
Absolute Event Rate: 2.8% vs 0.22%
p-value: p=<0.05
Short-term vitamin C supplementation attenuates postprandial endothelial dysfunction and oxidative stress following a high-fat meal in patients with Type 2 diabetes.
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Supports vitamin C as adjunct to blunt meal-induced endothelial impairment in T2D; extends antioxidant data to postprandial lipaemia.
Anderson et al. (2005) conducted an RCT in Type 2 diabetes (n=20). Vitamin C vs. Placebo was evaluated on Endothelial function assessed by flow-mediated vasodilatation (FMD) at 4 hours post-fat meal (p=<0.05). Vitamin C therapy (1 g for 2 days) attenuated postprandial lipaemia-induced endothelial dysfunction at 4 hours (FMD 2.8% vs 0.22%) and 8 hours in patients with Type 2 diabetes.
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