Why the study?
Does intravenous vitamin C improve endothelium-dependent vascular responses in hypertensive patients without relevant coronary artery stenoses?
Population
22 hypertensive patients without relevant coronary artery stenoses
Comparison
Intravenous infusion of 3 g vitamin C vs Intravenous infusion of placebo
Design
Other
Follow-up
immediately after intravenous infusion
Authors
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Supports oxidative stress role in hypertensive endothelial dysfunction; leaves open whether vitamin C alters clinical outcomes.
Does intravenous vitamin C improve endothelium-dependent vascular responses in hypertensive patients without relevant coronary artery stenoses?
Intravenous vitamin C improves endothelium-dependent vasomotor capacity of coronary arteries in hypertensive patients, suggesting oxidative stress contributes to endothelial dysfunction.
Solzbach et al. (1997) studied this question.
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