What question did this study set out to answer?

To evaluate acute changes in coronary flow reserve and coronary microcirculation after consumption of a single high-fat meal.

April 2, 2002Annals of Internal Medicine

Change in Coronary Flow Reserve on Transthoracic Doppler Echocardiography after a Single High-Fat Meal in Young Healthy Men

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Why the study?

Does a single high-fat meal reduce coronary flow reserve in young healthy men?

Population

15 young healthy men, mean age 29 +/- 4 years.

Comparison

Single high-fat meal vs Baseline and a single low-fat meal

Design

Other

Follow-up

5 hours

Authors

THTakeshi HozumiCardiac Imaging MEMarc S. EisenbergOsaka City University KSKenichi SugiokaOsaka City University

Discussion

Member takes

Implication

Transient CFR reduction after high-fat meal warrants caution around testing timing; leaves open long-term microvascular effects in patients.

Key Points

To evaluate acute changes in coronary flow reserve and coronary microcirculation after consumption of a single high-fat meal.
Controlled interventional study in 15 young healthy men (mean age 29 ± 4 years) conducted at university hospitals.
Assessed coronary flow reserve, blood lipid levels, and hemodynamic metrics using transthoracic Doppler echocardiography before and 5 hours after a high-fat meal (N=15) and a low-fat meal (N=5).
Triglyceride levels increased from 1.1 mmol/L to 2.8 mmol/L (P < 0.001), while mean coronary flow reserve fell from 4.02 to 3.30, representing an 18% reduction (95% CI, 13% to 23%) 5 hours post-high-fat meal.
Among the 5 men receiving both meals, coronary flow reserve decreased by 0.79 after the high-fat meal versus an increase of 0.07 after the low-fat meal (difference, -0.86 [95% CI, -1.36 to -0.37]; P = 0.03), accompanied by a larger triglyceride rise (difference, 1.5 mmol/L [95% CI, 0.3 to 2.7 mmol/L]; P = 0.03).

Structured PICO

Does a single high-fat meal reduce coronary flow reserve in young healthy men?

Population

15 young healthy men, mean age 29 +/- 4 years.

Intervention

Single high-fat meal

Comparator

Baseline (before meal) and a single low-fat meal (in a subset of 5 men)

Outcome

Change in coronary flow reserve measured by transthoracic Doppler echocardiography at 5 hourssurrogate

A single high-fat meal acutely decreases coronary flow reserve in young healthy men, suggesting a detrimental effect on coronary microcirculation.

Cite This Study

Hozumi et al. (2002) studied this question.

synapsesocial.com/papers/6a88181aafcf99b77fbbf8fa https://doi.org/10.7326/0003-4819-136-7-200204020-00009

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Implication

Transient CFR reduction after high-fat meal warrants caution around testing timing; leaves open long-term microvascular effects in patients.

Change in Coronary Flow Reserve on Transthoracic Doppler Echocardiography after a Single High-Fat Meal in Young Healthy Men

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Change in Coronary Flow Reserve on Transthoracic Doppler Echocardiography after a Single High-Fat Meal in Young Healthy Men

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider