What question did this study set out to answer?

To determine the diagnostic accuracy of 16-row multidetector computed tomography for detecting obstructive coronary artery disease using quantitative analysis in a multicenter setting.

July 25, 2006JAMA

Accuracy of 16-Row Multidetector Computed Tomography for the Assessment of Coronary Artery Stenosis

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Authors

MGMario J. GarcíaCardiac Imaging JLJonathan LessickTechnion – Israel Institute of Technology MHMartin HoffmannFraunhofer Institute for Toxicology and Experimental Medicine

Discussion

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Implication

Prospective multicenter study demonstrates high sensitivity but low specificity for 16-row MDCT in suspected coronary disease, indicating limited routine clinical utility.

Key Points

To determine the diagnostic accuracy of 16-row multidetector computed tomography for detecting obstructive coronary artery disease using quantitative analysis in a multicenter setting.
Prospective multicenter study across 11 sites enrolling 238 patients referred for nonemergency coronary angiography between June 2004 and March 2005.
A total of 187 patients with an Agatston score below 600 underwent contrast-enhanced 16-row MDCT followed 1 to 14 days later by conventional coronary angiography, evaluated by independent core laboratories using quantitative coronary angiography.
For detecting >50% luminal stenosis (with 71% of 1629 segments evaluable and nonevaluable segments censored as positive), segment-based sensitivity was 89%, specificity was 65%, PPV was 13%, and NPV was 99%; patient-based sensitivity was 98%, specificity was 54%, PPV was 50%, and NPV was 99%.
For detecting >70% luminal stenosis (nonevaluable segments censored as positive), segment-based sensitivity was 94%, specificity was 67%, PPV was 6%, and NPV was 99%; patient-based sensitivity was 94%, specificity was 51%, PPV was 28%, and NPV was 98%.

Cite This Study

García et al. (2006) studied this question.

synapsesocial.com/papers/6a11e4bb0db2e61b4b8e104d https://doi.org/10.1001/jama.296.4.403

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Implication

Prospective multicenter study demonstrates high sensitivity but low specificity for 16-row MDCT in suspected coronary disease, indicating limited routine clinical utility.

Accuracy of 16-Row Multidetector Computed Tomography for the Assessment of Coronary Artery Stenosis

Discussion

Member takes

Implication

Key Points

Cite This Study

Accuracy of 16-Row Multidetector Computed Tomography for the Assessment of Coronary Artery Stenosis

Discussion

Member takes

Implication

Key Points

Cite This Study

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